According to 2011 Ethiopian demographic health survey the national adult HIVrnprevalence is 1.5 %. In the same survey, HIV prevalence was 2.2% in the Amhara Region. In thernregion of North West Ethiopia, 88.9% of pre-ART PLWHA has any type of OI at initiation ofrnART. Different studies showed the effect of ART improves time to death of PLWHA however,rnlittle is known about its effect on improving time of recurrence of OI and factors associated withrnit and magnitude of the recurrence. Hence this study will be used to plan resources needed forrnchronic HIV/AIDS care and to identify factors affecting patientsâ€™ survival.rnObjective: To assess time to recurrence of OIs and factors associated with it and to determinernmagnitude of recurrence in PLWHA in Debre Markos town in 2013.rnMethod: Institution based comparative retrospective cohort study were used and the requiredrnsample size was 536. All 18 years old and above PLWHA who were on chronic HIV care inrnDebre Makkos town health institutions was the source population for the study. Studyrnparticipants were selected from the list of PLWHA attending the public health facilities usingrnsimple random sampling procedure by data collectors who are working in ART clinic. Univariaternanalysis was used to describe patientsâ€™ baseline and follow up characteristics. Actuarial life tablernand Kaplan-meier survival was used to estimate survival and log rank test was used to comparernsurvival curves. Cox proportional-hazard regression model was used to calculate the uni-variaternand adjusted hazard rate and to determine independent predictors of time to recurrence of OI.rnResult: Among study participates 66% were females and the median age was 32 years. Most ofrnthem were urban 70.1%, orthodox 92.4%, not educated 44%, married 43.3% and employed 20%.rnDuring a median of 43 person weeks follow up OIs recurred in three quarter (75.7%) studyrnparticipants. The Incidence rate of OI recurrence was 13.1(95 CI: 11.9-14.5) per 1000 personrnweeks. Using the Kaplan-meier survival estimation the median time of survival was 57 weeks.rnAfter adjusted for covariates the significant predictors for survival were marital status,rnoccupational status, follow up CD4 count, base line Hgb value, ART exposure status, base linernART adherence status, base line and follow up prophylaxis exposure status and follow uprnprophylaxis adherence status,rnConclusion and recommendation: Governmental and non-governmental organizations workingrnon HIV/AIDS should give especial attention for risk groups like widowed, not taking treatment/rnadhere ART or prophylaxis while continuing HIV care for all PLWHA.