Back ground: Podoconiosis is non-infective, usually crystalline Blockage of the limbrnlymphatic, almost always affecting the lower limbs. In Ethiopia Podoconiosis is an importantrnpublic health problem in endemic areas like Wolaita zone. Podoconiosis has a serious socialrnand psychological burden. The importance of assessment of quality of life has gainedrnconsiderable value in recent years .There are several benefits of measuring QOL.rnObjectives: The objective of the study was to asses the applicability of DLQI in measuringrnthe quality of life of Podoconiosis patients.rnMethods: A cross sectional study was conducted in wolaita zone, SNNPR Ethiopia in eightrnMFTPA`s outreach sites using the translated Amharic version of DLQI.rnResults: the questioners were administered to 148 Podoconiosis patients, 80 males and 68rnfemales. Patients' ages ranged from 17-78 years (mean 35.95 years, SD 16.112,).fifty percentrnwere new patients and the rest were patients treated for a minimum of three months atrnMFTPA. Twenty eight (18.9%) of patients were from urban areas and the rest were from ruralrnsites. The Cronbach`s alpha was 0.71 among treated patients and 0.78 among new patients.rnItem total correlation ranged from 0.39-0.47. The DLQI score for new patients ranged from 4rnto 21 (mean 12.76, median 13.00, SD 3.81) and those for treated patients ranged from 1 to 18rn(mean 4.08, median 3.00, SD 3.16). The ranked mean difference between the two groups wasrnstatistically significant. (Z=-0.9477, p value< 0.000). There was no statistically significantrndifference between age, sex and outreach sites groups regarding the overall DLQI score.rnConclusions: In conclusion it was found that the Amharic version of the DLQI was a valid,rnreliable and acceptable for measuring the quality of life of Podoconiosis patients in the studyrnsettings and a three or more month treatment by MFTPA is associated with improving thernquality of life.