Outcome of patients with Acute Coronary Syndrome admitted to Tikur AnbessarnSpecialized Hospital, Addis Ababa, EthiopiarnKassahun BogalernAddis Ababa University, 2017rnWorldwide, coronary artery disease (CAD) is the single most frequent cause of death. Overrnseven million people every year die from CAD, accounting for 12.8% of all deaths. Thernobjective of this study was to assess the treatment outcome and associated factors for AcuternCoronary Syndrome (ACS) patients admitted at Tikur Anbessa Specialized Hospital (TASH). Arnretrospective cross sectional study was conducted by chart review of patients who wererndischarged with a diagnosis of ACS during the period January 1, 2012 to December 31, 2014. Ofrn124 ACS patients who were admitted during the three years period, 90(72.6%) were diagnosedrnas STEMI. The mean age was 56.3 Â±13.7 years. The average length of hospital stay was 9.77Â±rn6.42 days. The average time from onset of ACS symptoms to presentation in the emergencyrndepartment was 3.8 days (91.7 hours). In about 76 (61.3%) patients hypertension was the leadingrnrisk factor for development of ACS. 36.4% of ACS patients in TASH were either Killip class IIIrnor IV. Biomarkers were measured for 118(95.2%) patients. 79.2% of patients had ejectionrnfraction (EF) of less than 40% and 29.2% had less than 30%. In-hospital medications includernloading dose of aspirin (79%), anti-coagulants (77.4%), beta-blockers (88.1%), statins (85.5%),rnmorphine (12.9%), and nitrates (35.5%). The in-hospital mortality was 27.4%. Predictors of inhospitalrnmortality in TASH included age (P=0.042), time from symptom onset to presentationrn(P=0.001), previous history of hypertension (P=0.025), being Killip class III and IV (P=0.001),rnand STEMI diagnosis (P=0.005). Hence, based on the results the medical management of ACSrnpatients in TASH was in line with the recommendations of international guidelines but inhospitalrnmortality was very high (27.4%).rnKey words: Acute Coronary Syndrome, Outcome, In-Hospital Mortality