Girls Preference For Human Papilloma Virus Vaccination In Secondary Schools In Addis Ababa Ethiopia 2017 Discrete Choice Experiment

Background: There are three HPV vaccines that are safe and effective for protecting HPVrninfection. These are: bivalent which protect from HPV type 16 and 18, quadrivalent for HPV typern6, 11, 16 and 18, and nonavalent for HPV type 6, 11, 16, 18, 31, 33, 45, 52 and 58. About 7,000rnnew cervical cancer cases are diagnosed annually in Ethiopia. It is the second cause of cancerrnrelated death in women aged 15 to 44 year. Even thouge Ethiopia undergo a pilot for HPV vaccinernimplementation at two sites in Oromia Region, Jimma zone, Gomma woreda and Tigray RegionrnAhiferom Woreda with support of GAVI, there is no data that show a finding regarding the currentrnstatus of receiver’s attitude, acceptance, and mainly girls’ preference for HPV vaccine.rnObjective: The aims of this study was to rank the contribution of the attributes for HPVrnvaccination; and to measure the willingness-to-pay, the trade-offs, and choices of girls betweenrnrisk and benefits of the vaccination.rnMethods: The study was done by using discrete choice experiment (DCE). The data was collectedrnfrom Februray to March 2017 among 4 different secondary schools in Addis Ababa. A total of 336rngirls aged 15-18 year were included in the study. The vaccination program attributes considered inrnthe choice experiment were: degree of protection against cervical cancer, duration of protection,rnage at vaccination, number of doses, risk of developing serious side effects, price of vaccine, andrnway of delivery. Each choice set of all determined options were put in to mixed logit model torndetermine the sign of the coefficient of each attributes. Trade-offs and WTP also determined.rnResults: From all participants, only six of them had been vaccinated for HPV. Doctorsrnrecommendation (34.9 %), mass-media campaign (81%) and positive familys’ opinion (80 %) werernfactors encouraging respondents to get the vaccination. Girls were willing to trade-off 5 % ofrnprotection against cervical cancer in order to get HPV vaccination which had protective durationrnof 25 years instead of 8 years. On average the respondents were willing to pay 153 ETB for anrnimprovement in protection against cervical cancer from 70 % to 98 %.rnConclusion: There was significant variationeof preference among girls for all HPV vaccinernattributes. Degree of protection, number doses, and the risk of serious side effect were the threernmost important attributes which guide the choice of girls, while cost of the vaccine had been thernleast important factor. We found high level of tradd-offs level of protection against number ofrndoses, seriouse side effects and place of delivery

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