Background: Recently, Khat chewing has become a common practice worldwide. It causes andrnpredisposes a significant physical and mental health, and social-economic crisis. However,rnbehavioral intention to khat chewing is not well studied yet in Ethiopia. rnObjectives: To assess intention to khat chewing among youths in Raya-Azebo district, SouthernrnTigray, Ethiopia, 2019. rnMethods: A community-based cross-sectional quantitative study among randomly selected 627rnyouths in Raya Azebo district, Northern Ethiopia was conducted in 2019. Data were collectedrnusing a pre-tested structured interviewer-administered questionnaire. Epi Data version 4.4.2 wasrnused for data entry then exported to SPSS version 25 for data analysis. A multivariable linearrnregression model was used to predict the contribution of independent variables and identifyrnvariables strongly associated with intention to khat chewing among youths. The goodness of fitrnmodel was checked and P-value ≤ 0.05 was used to declare statistical significance. rnResults: The response rate of the study was 97.82%. A considerable proportion, 192 (30.62%) ofrnyouths had an intention to chew khat in the next 6 months. The direct components of theory ofrnplanned behavior (TPB) were predicted by their respective indirect components. The componentrnof TPB independently explained the variance in intention to khat chewing by 83.0%. TPBrnconstructs and Socio-demographic, Knowledge, and past behavioral experience variablesrnexplained the variance in intention to khat chewing by 83.20%. The strongest predictors ofrnintention to khat chewing were attitude (β= 0.350, P