Background- Adolescent overweight and obesity is a global public health problem andrnassociated with increased risk of metabolic syndrome. Recently, mid-upper arm circumferencernhas been suggested as a screening tool for overweight and obesity among school age childrenrnand early adolescent. However, little is known about the potential use of mid-upper armrncircumference in late adolescents (15-19 years).rnrnObjective- The aim of the study was to evaluate the ability of mid-upper arm circumference torncorrectly identify BMI-for-age z-score defined overweight and obesity among adolescents inrnselected high schools of Addis Ababa, Ethiopia, 2019.rnrnMethods- A school-based cross-sectional study was conducted among 851 late adolescents inrnAddis Ababa. A stratified multi-stage sampling procedure was followed. A pre-testedrninterviewer-administered questionnaire was used. Anthropometric measurements includingrnweight, height, and mid-upper arm circumference were measured. Receiver operatingrncharacteristic curve analysis was done to determine the ability of MUAC to detect overweightrnand obesity. Sensitivity, specificity, predictive values and likelihood ratio of MUAC wererncalculated for the optimal cutoff points. rnrnResult - MUAC had strong positive correlation with BMI-for-age z-score (r = 0.84). Therndiagnostic performance of MUAC as assessed by area under the curve (AUC) for identifyingrnoverweight and obesity was 0.96 for both genders. The optimal mid upper arm circumferencerncut off point was ≥ 27.9 cm with sensitivity of 90.28%, specificity of 90.71%, positivernlikelihood ratio of 9.72 and negative likelihood ratio of 0.11 for girls. Similarly, for boysrnoptimal mid upper arm circumference cut off point was ≥ 27.75 cm with sensitivity of 94.1%,rnspecificity of 89.1%, positive likelihood ratio of 8.7 and negative likelihood ratio of 0.07.rnrnConclusion - This study provide evidence that MUAC have high specificity and sensitivity tornidentify overweight/obese among late adolescences as evaluated against body mass index forrnage z-score. The optimal mid upper arm circumference cut off point for girls was ≥ 27.9 cmrnand for boys was ≥ 27.75 cm. MUAC have potential for screening and surveillance applicationsrnas simple and widely available indicator of overweight/obesity in late adolescents.