Background: The health care waste generation rate highly varies among health providersrndue to factors such as the number of patient flow, size of the facility, types of facility, andrnservice. There is no effective health care waste management practice in most less developedrncountries including Ethiopia. There is lack of research which elaborated more detail the mainrncause of high proportion of hazardous wastes generation in comparission to general waste,rnand mean waste generation per patient flow in studied health facility. rnObjective: To assess health care waste generation rate, its characterization and managementrnpractice in health centers of Nifas Silk Lafto Sub-city, Addis Ababa. rnMethods: Cross-sectional study was conducted from June to July 2020. Ten health centersrnfrom Nifas Silk Lafto Sub-city were selected purposely due to poor waste management, lackrnof adequate knowledge and commitment within the community and health provider. Datarnwas collected by FMHACA Environmental health professionals using observationalrnchecklist and weight scale for period of 7 consecutive days from june 15- 21/2020. Training,rnpre-test, and instrument calibration were used to manage data quality. Collected data wasrnorganized and entered in Epi data version 7 and cleaning was done to avoid missing values,rnoutliers, and other inconsistencies. Cleaned data then exported into SPSS version 20 forrnanalysis and One way ANOVA test was done. rnResults: The daily mean(Â±SD) healthcare waste generation rate was 5.51Â±1.455kg/day,rnwhich was equivalent to 0.074Â±.016kg/pat/day. Out of the total waste generated (27.40%)rnwas general and (72.60%) was hazardous waste. Most generation was from OPD, which wasrn72.3kg/week (18.76%).The proportion of sharps (32.02%), infectious (38.85%), pathologicalrn(8.18%), pharmaceutical (20.94%) and general waste (27.4%). Healthcare waste generationrnrate varies by number of patient flow with(p