Background: The job of waste cleaners are characterized by lifting, pulling, carrying and pushing healthrncare wastes containers that potentially expose them to different ergonomics problems and physical injuries.rnThere are also hazardous and nonhazardous wastes that requires due attention. There exist a concern thatrnhazardous and nonhazardous waste may lead to the occurrence of high degree of sharp related injuries.rnObjectives: This study was conducted to determine the prevalence of occupational injury and to identify thernoccupational associated factors that lead to the development of occupational injury among waste cleaners inrngovernmental hospitals of Addis Ababa city.rnMethods: This study was conducted on governmental hospitals found in Addis Ababa city, Ethiopia usingrncross-sectional study design among 403 cleaners. Data was collected using structured questionnaire,rnobservational checklist and then verified. Odds ratio with 95% confidence was calculated to check whetherrnthere is association between selected independent variables and occupational injury or not. Multivariaternlogistic regression was also used to see the relative effect of one independent variable on occupational injuryrnby controlling the other independent variables.rnResults: Among 398 study participants, 390(98%) of them were female and male accounts 8(2%). Thernmean age of the respondents were 28.6 with a minimum of 14 and a maximum of 70. Most of thernrespondents (100%) used personal protective equipment while they are on duty. Out of 398 governmentalrnhospital cleaners, 47 (11.8 %) with 95% CI (8.8, 15.3) of them were reporting physical injury in the past onernyear due to their occupation. Family size, working hours per day and sleeping disorder are associated withrnthe independent variable. As compared with who had five and more family, the odds of occupational injuryrnwho had two and less (AOR = 0.42, 95% CI: 0.191-0.936) and three to four family (AOR = 0.43, 95% CI:rn0.193-0.959) were reduced by almost half. And Occupational injury of respondents who works for above 8rnhours (AOR = 2.17, 95% CI: 1.08-4.37) were 2.17 more likely exposed than those who works 8 and below.rnIn addition, the occupational injury of those who had not sleeping disturbance (AOR = 0.16, 95% CI: 0.083.33)rnwerernalsornreducedrnbyrn84%rnasrncomparedrnwithrnwho facedrnsleepingrndisorder.rnrnConclusion: Occupational injury among waste cleaners in Addis Ababa governmental hospitals needs arnpublic health intervention. Hence, job rotation, improvement of employsâ€™ income and provision of sufficientrnPPE are highly recommended. Periodic health surveillance of cleaners is also advisable to early identify andrndetect work related compliant.