Ethiopia is a developing countly with a demographic profile dominated by a young population.rnDue to biological, socio-cultural and economic factors, young people, particularly those aged 14-rn19 yp'lrs, are generally at a high risk of H1VIA1DS and other reproductive health problems.rnThis study is intended to examine gender differences in adolescent sexual behavior andrnreproductive health risks in Bahir Dar town. A cross-sectional, study was conducted in Bahir Darrntown. Both quantitative and qualitative data-collection methods were employed to conduct thernstudy. For quantitative data collection, a household interview survey was conducted among 630rnmales and 693 female's adolescents, aged 14-19 years, within the 5 randomly selected Kebeles ofrnthe town and conducted four focus-group discussions, with 40 participants, /0 collec/ed qualitativerndata. Logistic regression analysis was used to examine the influence of the explanatOlY variable onrnthe dependent variables using the SPSS version 13. The study examined gender differences inrnsexual initiation, unsafe sexual behavior, condom use, sexually transmitted diseases and abortion.rnLogistic techniques reveal that younger females were more likely than older females to havernbecome sexually active by early age. Adolescents currently enrolled in school were less likely tornhave begun early sexual activity, particularly females. Females who discussed sexual issues withrnfriends were more likely to initiate early sexual activity than males. Among sexually experiencedrnadol"~cents 65.2% of males and 59.1% of females had two or more sexual partners in thernprevious year. The proportion with multiple partners Significantly increased with age. Around 50%rnof females and 60% of males aged 14-19 years had used condoms at least once, while only 17.9%rnof females and 26.4% of males used condom during Ihe last intercourse. Risk of having arnsexually Iransmitted disease in the previous year was higher for both fell/ales and males who havernmlilliple sexual partners. Because of early and unprotected sexual initiation, and subsequent highrnrisk sexual behaviors characterized by multi-partnered sex and no or inconsistent condom usernadolescent in Ethiopia are at significant riskfor reproductive health problems, including HIV, STDrnand unwanted pregnancy. Gender-based interventions for adolescents should be given at earlierrnage and strategies for delaying sexual initiation as well as ejJective skills and methods for thernprevention of HIVIAIDSISTD and unwanted pregnancy should be adopted.