Background: Postoperative complications after thyroidectomy are problematic for patients andrnsurgeons. The postoperative outcome of thyroidectomies is related to risk factors concerning thernpatient, the thyroid disease and the surgeon. Thyroidectomy complications may be divided intorntransient or permanent. The transient may vary from severe, life threatening ones, all the way tornmild and meaningless events. Permanent complications, which prevalence is variable, represent thernmain concern of those who treat thyroid diseases surgically. Despite its importance, the risk factorsrnassociated with post-thyroidectomy complications are not enough analyzed.rnObjectives: To evaluate factor affecting post thyroidectomy outcome in three teaching Hospitals inrnAddis Ababa Ethiopia.rnMethod: A prospective study was conducted in surgical department of Black Lion, Yekatit andrnZewuditu Memorial Hospital. The study has included patients diagnosed for thyroid swelling andrnoperated from October 1 2019 â€“April 30, 2020, meeting the following criteria: MNG; operation byrnsurgeons with various experiences; and minimum follow-up of 1 month. Age, thyroid function test,rnindication for surgery, types of surgery, surgeon experience, intraoperative adhesion and estimatedrnblood loss were analyzed as risk factors for post thyroidectomy outcome.rnData was analyzed using SPSS version 20.0. P values < 0.05 were considered statisticallyrnSignificant.rnResult: During the study period 120 thyroidectomies were performed. There were 20 (16.66%)males and 100 females (83.33%)with Male to female ratio was 1:5.Total Thyroidectomy+,LNDrnperformed in 4(3.3%) and Total thyroidectomy alone was performed in 10(8.3.%) patients. Totalrncomplications occurred was 23 (19.16%) in 120 patients. Wound infection was the mostrncomplication seen in 7(5.8%)of patients and hematoma was seen in 6(5%)patients. 3(2.5%)ofrnpatients suffered from recurrent laryngeal nerve palsy and hypocalcemia.rnThere was association b/n early postoperative complication withrnage (p value=.025rnbrn), Indication for Surgery (p value.031rnb,rn)and type of surgery (p value.045rn).rnEstimated Blood Loss was significantly associated with hematoma (p value.000rnbrnbrn). Earlyrnpostoperative complication also has significantly associated with thyroid function test (prnvalue.005rnbrn), adhesion (p value.035b) and operating surgeon (p value .022b).rnno association b/n early postoperative complication with, size and duration of goiterrnThere was no postoperative mortality in this study.rnConclusionrnThe factors affecting post thyroidectomy outcome were indication for surgery, estimated blood loss,rntype of surgery, thyroid function test, adhesion and surgeon experience.rnPatient with these factors should be advised for possible higher rate of complications and thernsurgeon should be prepared beforehand.rnRecommendation:rnPatients with thyroid malignancy, with considerable intraoperative bleeding needs carefulrnhemostasis, can rebleed and develope hematoma.rnFurther study is necessary to identify the cause of wound site infection as commonest complicationrnobserved was sugical site infection.