The only way to solve the problem of I-f/VIAIDS is prevention than treatment by identifYing the majorrnf actors responsible for its drastic distribution. This paper tries to find the major factors that arernresponsible for the distribution of HIV AIDS in Addis Ababa and Nazareth. Therefore, the objectivernof this paper is to find out the major f actors thaI are responsible for the distribution of HIV epidemic.rnSpecifically, it is intended to:rn1. identifY the demographic factors those are associated with HIVrn2. identifY the unique behavioral characteristics that lead to HIV infectionrn3. explore the effect of socio-cultural factors on HIV distributionrn4. explore the impact of the socio-economicfactors on HIV distributionrnThe study was conducted by distrib liling questionnaires with four categories of questions to HIVrnvictims waiting medication in hospitals and in Dawn Hope of Ethiopia offices. The data are thenrnanalyzed by categorizing to four sections I) Analysis of behaviors versus demographic variables, 2)rnBehavioral versus Behavioral variables, 3) Behavioral versus economic variables and 4) Behavioralrnversus social-cultural variables. The data collected from 100 HIV patients in hospitals and DawnrnHope of Ethiopia in Addis Ababa and Nazareth is analyzed by using cross tabulations andfrequencyrntables to observe the association of one variable on the behaviors of individuals that are susceptivernfor HIV infection. To decide on the existence of association between a pair of variable using chirnsquare test of independence, coefficient of contingencies were computed Variables that arernassociated with some behaviors such as lIIultiple sexes, drug addiction and others are explained inrncross tabular forms and bar charts. The result indicated that the behavioral variables such as drugrnaddiction, openness and interest to exchange about HIV and Condoms and the demographicrnvariables such as sex, marital status, age and place of birth are the major factors for the distributionrnof HlVIAIDS follow ed by socio-economic factors such as occupation, average income and housingrnissues. But the socio-cultural factors such as rape, tal/ooing, ear piercing and FGM are found tornhave insignificant effect on the distribution of HIVIAIDS in Addis Ababa and Nazareth.