The purpose of this study was to assess the Psycho-Social Influence of Cigarette Smoking among Senior Secondary School Students, the specific objective of the study are Sociological influence of cigarette smoking among Senior Secondary School Students and the Psychological influence of Cigarette Smoking among Senior Secondary School Students in Taraba State, Nigeria. To achieve this purpose, ex-pot-facto research design was considered suitable for this study. The population for this study comprises of senior secondary school students in Taraba state. The sample size for this study was 364 students questionnaire. A multi â€“ stage sampling procedure was used to draw the respondents from Senior Secondary School students in three existing senatorial zones. The instrument used for this study was a researcher developed questionnaire. Three hundred and sixty-four (364) copies of questionnaire were distributed to the respondents while three hundred and fifty eight (358), (98.6%) were dully retrieved. Descriptive statistics of frequency and percentage, mean and standard deviation were used in analyzing and presenting the results. One-sample t-test and analysis of variance (ANOVA) were used. The results of the study revealed that, there is sociological influence (lifestyle, environment, and peer group) of cigarette smoking among senior secondary school students in Taraba state, Nigeria with a t-value of 142.680, (p-0.000); also there is psychological influence (worries, frustration, anger and anxiety) about cigarette smoking among senior secondary school students in Taraba state, Nigeria. On the basis of these research findings, the following conclusions were drawn that, there is sociological influence (environment, lifestyle, peer group) on cigarette smoking among senior secondary school students in Taraba State, Nigeria. Psychological influence (Anger, depression frustration and anxiety) about cigarette smoking also exists among senior secondary school students in Taraba State. On the basis of the conclusions drawn, the researcher recommended that, Sociologists, Health counselors and Health Educators should carry out enlightenment programme on the menace of cigarette smoking among students and School principals in collaboration with psychologists in the secondary schools should educate students to desist from cigarette smoking in curbing anger and depression.