Effect Of Aqueous Extract Of The Bark Of Kha Ya Senegalensis On Phenylhydrazine Induced Anaemia

Phytochcmical screening was conducted using petroleum ether (40 - 60°C), melhanolic and aqueous extract of the stem bark. Both the methanolic and aqueous extracts gave positive result to carbohydrates, saponin glycosides and tannins. In addition, terpenes and anthraquinoncs were found only in the methanolic extract. The petroleum ether extract contained only steroids. Data on the mineral content of the aqueous extract of the bark showed that it is rich in some of the important mineral element needed for the development and functioning of blood. Trial experiment to determine the suitable dose of phcnylhydrazine for induction of anaemia in rats showed that 750mg/kg body weight would give a suitable anaemic condition. /// vivo investigation of the effect of oral daily dose (300mg/kg body weight) of the bark aqueous extract on phcnylhydrazine - induced anaemia in rats did not show any significant curative effect (P > 0.001). However, the same oral dosage seemed to produce significant (P < 0.001) Prophylaltic effect probably by protecting the red blood cell against Phcnylhydrazine destruction. Subcutaneous injection of 30mg/kg body weight on Trypanosoma brucei induced anaemia in the rats did not produce anaemia or trypanocidal effect.

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