Effect Of Aqueous Extract Of The Bark Of Kha Ya Senegalensis On Phenylhydrazine Induced Anaemia

Phytochcmical screening was conducted using petroleum ether (40 - 60°C),melhanolic and aqueous extract of the stem bark. Both the methanolic and aqueousextracts gave positive result to carbohydrates, saponin glycosides and tannins. In addition,terpenes and anthraquinoncs were found only in the methanolic extract. The petroleumether extract contained only steroids. Data on the mineral content of the aqueous extractof the bark showed that it is rich in some of the important mineral element needed for thedevelopment and functioning of blood. Trial experiment to determine the suitable dose ofphcnylhydrazine for induction of anaemia in rats showed that 750mg/kg body weightwould give a suitable anaemic condition. /// vivo investigation of the effect of oral dailydose (300mg/kg body weight) of the bark aqueous extract on phcnylhydrazine - inducedanaemia in rats did not show any significant curative effect (P > 0.001). However, thesame oral dosage seemed to produce significant (P < 0.001) Prophylaltic effect probablyby protecting the red blood cell against Phcnylhydrazine destruction. Subcutaneousinjection of 30mg/kg body weight on Trypanosoma brucei induced anaemia in the rats didnot produce anaemia or trypanocidal effect.

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