A cross sectional study of contagious caprine pleuropneumonia in goats was conducted from October 2005 to March 2006; to determine seroprevalence, pathology and Mycoplasma species involved in pneumonic lungs of goats slaughtered at ELFRA export abattoir. Laboratory work was carried out at National Veterinary Institute (NVI). A total of 704 sera were collected from goats that purchased from Awash (n= 224), Dire Dawa (n =200) and Borana (n =280). Using the Complement Fixation Test (CFT) an overall prevalence of 48.3% (95% CI 47.4 -52.1%) was obtained. The prevalence in Awash, Dire Dawa and Barana were 47.3% (95% CI 41.2- 54.3%), 44.5% (95% CI 38.1-51.9%) and 51.8% (95% CI 46-58%) respectively. There was no significant difference (p>0.05) in seroprevalence among three origins, as well as no statistical significance (p>0.05) among individual ages of goats. A serial c-ELISA was also conducted on CFT positive sera; accordingly an overall prevalence of 11.8% (95% CI 8.8 - 15.7%) was recorded. Seroprevalence in Awash, Dire Dawa and Borana were 17% (95% CI 11.1 - 25.9%), 5.6% (95% CI 2.4 - 13.2%) and 11.7% (95% CI 7.5 - 18.3) respectively. There was significant difference (p