Livestock is the pillar of the livelihood of the majority of Ethiopians, however, profitability of thernsector is hindered by multifaceted constraints, of which livestock diseases are the majorrncontributing factors. The current case studies described clinical cases of various diseases andrntheir management in different species of animals brought to Veterinary Teaching Hospital andrnSPANA, Ethiopia animal health facilities of Addis Ababa University, College of VeterinaryrnMedicine from Bishoftu and its vicinity. Young and adult animals of different species,rnphysiological stages and sexes were examined from November 2017 to June 2018. Thernexamination method involves owner complaint and detail clinical examinations. Animals wererntreated vigorously based on tentative diagnosis using broad-spectrum antimicrobials andrnsupportive drugs based on the manufacturer instructions. Simultaneously, samples from thernindividual animals examined tentatively were collected and processed following appropriaternlaboratory procedures to reach on definitive diagnosis. The cases were then followed until thernanimal recovered either in the clinic during the successive therapies or at home for the diseasesrnwith prolonged recovery. A total of 28 animals were examined of which 89.3% (25/28) werernruminants while 10.7% (3/28) were equine and canine. Among these, 35.7 % (10/28), 28.6 %rn(8/28), 17.9 % (5/28), 10.7% (3/28), 7.1% (2/28), of the diseases were caused by bacteria, virus,rnparasites, miscellaneous, and metabolic, respectively based on clinical pictures and laboratoryrnresults. Among the treated animals 82.1 % (23/28) were recovered, 14.3 % (4/28) (two goats, onernsheep, and one calf) died and one bull was refractory. Therefore, this study showed bacteriaâ€Ÿs andrnviruses were the most common disease causing agents followed by parasites. In general, highestrnproportions of animal diseases could be cured if appropriate management and rational drug usernapplied on time and appropriately. Based on this finding, training of animal health workers,rnconstruction of inpatient facility and installing advanced diagnostic tools were recommended tornfacilitate the routine animal health care works and reduce the losses of diseases.