Herd level cross-sectional and calf level longitudinal observational study was conducted between November 2014 to April 2015 in peri-urban and urban dairy farms of Bahir Dar milk-shed, Ethiopia. The aims of this study were therefore, to determine the incidence rate of calf morbidity and mortality, investigating potential determinant factors of calf morbidity and mortality and to determine the passive transfer of immunity in some selected dairy calves. Both concurrent and prospective cohorts were employed to recruit calves aged below 6 month in the study herds. A total of 440 calves, a random sample of 322 calves from small-holder and 118 from five large dairy farms located in Bahir Dar milk-shed were included in the study. Each study calf was individually ear-tagged and regularly monitored in monthly basis for clinical health problems up to an age of six months. Information on different potential risk factors was collected by using herd and calf level recording sheets and personal observations. Serum samples were taken from some study calves to determine their level of passive transfer and it was conducted in Bahir Dar Animal Health Diagnostic and Investigation Laboratory.rnThe overall incidences of crude morbidity and crude mortality rates found in this study were 47.3% and 17.9%, respectively. Calf diarrhea, pneumonia, navel ill, septicemic conditions, Lumpy Skin Disease, rabies, congenital problems and other miscellaneous cases were encountered during this study. The most frequent disease condition was calf diarrhea with the incidence rate of 25.2% followed by pneumonia (8.6 %). The incidence of crude mortality was apparently higher in large sized dairy farms than smallholder farms. However, calf diarrhea and crude morbidity rates were higher in the latter. About six, 6, 4 and 2 explanatory variables were found significantly associated with crude mortality, crude morbidity, diarrhea and pneumonia respectively by multivariate Cox-regression at P