Evaluation Of Antimalarialactivity Of Otostegiaintegrefolialeaf Extracts Againstplasmodium Berghei In Mice

Malaria remains one of the most deadly parasitic diseases in the tropics and subtropics. It is therncause of death of more than 650,000 people every year with the majority affected groups arernchildren under the age of five and pregnant women. The spread of drug resistant malaria parasiternis the major challenge in the control of the disease. Therefore, there is an urgent need to developrnnew and efficient antimalarial drugs that are easily be accessible and affordable by those poorrnliving in the malarious regions. In the attempt to search for new antimalarial drugs, the presentrnstudy aimed to discover an effective plant based extracts from the leaf of Otostegia integrefoliarnagainst chloroquine (CQ) sensitive strain of Plasmodium bergheiin vivo in Swiss albino mice.rnThe standard 4-day suppressive test was employed to determine percent parasitaemia inhibitionrncaused by extracts of the plant material. Extracts were administered at doses of 200, 400 and 800rnmg/kg body weight (b.wt) of mice. Aqueous, methanol and chloroform crude extracts of the leafrnof O. integrefolia suppressedP. berghei parasitaemia significantly (P

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