Typhoid fever is a febrile illness caused by the Gram-negative bacterium Salmonella enterica subspecies enterica serotype typhi. Objective of the study was to determine the prevalence and associated risk factors of typhoid fever among patients visiting Gura Damole Health Center in Southeast Ethiopia. The study was a health facility based descriptive quantitative cross-sectional survey between October 2018 and February 2019. A standardized questionnaire was used to collect socio demographic data and other related factors. Venous blood was collected for the Widal test. Data were coded, entered, checked for completeness, and analyzed using SPSS version-23 statistical software. Binary logistic regression tests were used to identify significantly associated risk factors. A p-value