A birth defect (BD) can be defined as any structural or functional abnormality determined by factorsrnoperating largely before conception or during gestation. It may be recognized prenatally, duringrndelivery or in postnatal developments. The main objective of this study was to document and analyze datarnon the prevalence of birth defects and assess possible risk factors in selected Hospitals and Healthrncenters in Addis Ababa. These selected hospitals and health centers were Menelike II GeneralrnSpecialized Hospital, Kotebe Health center,Jalmeda Health center, Kebena health center, KotebernMillennium Health center and Denbrua Hospital . Data were collected from Hospitals and Healthrncenters by questionnaire and medical records between September 2019 and August 2020.during the studyrnperiod the total birth of 52321were recorded in the selected hospitals and health centers out of this aboutrn107infants was born with birth defects. This is about 0.2% or2 per1000 birth. from those mothers only 25rncould participates in questionnaire. In this research five types of birth defects have been identified. Thernmost frequent type of birth defect was Down syndrome 32.7%, while the least frequent was or facial cleftrn7.47%. This difference was statistically significant (p=0.00). The infant mother age showed a directrnrelationship with defective birth where older mothers had higher probability for births with BDs. Thisrnwas also supported by the presence of a statistically significant difference between younger and olderrnmothers with BDs (p=0.001). In addition, about 80% of defective children mothers follow parental carernbut only 32% do so from the beginning of their pregnancy while 48% started follow-up at a later stage.rnEven though 60% of mothers take folic acid, only 16% take folic acid from the beginning of theirrnpregnancy while 44% had started taking folic acid at later stage of their pregnancy. Moreover, aboutrn60% of mothers that consume alcohol also had defective births, while smoking had a slight significancernfor birth defects the percentage of female infants with birth defects compared to males was higher 57% vsrn43% . But this difference was not statistically significant (0.147) therefore the finding of this researchrnindicated the disuse and inappropriate use of folic acid, alcohol consumption, smoking, maternal age,rnand lack of prenatal care follow up properly are possible risk factors with the occurrence of birthrndefects.