Laggera tomentosa is a perennial fragrant bushy herb endemic to Ethiopia. It is a wellrnknown medicinal plant. The juice of the crushed plant is ingested as a treatment forrnstomach-ache and is also used against migraine. Phytochemical investigation on thernethanol extract of the leaves of this plant resulted in the isolation of one sesquiterpenernand one flavone, namely 3-(3’-acetoxy-2’-hydroxy-2’-methyl butyryl)- cuauhtemonern(LTE-7) and 3’,5,6-trihydroxy-3,6-dimethoxyflavone (LTE-8), respectively.