Mechanisms For Reduction Of Model And Anticancer Active Platinum(iv) Compounds By Biological Molecules

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Electron transfer reactions of model and anticancer active platinum(IV) complexes with thiolsrnand ascorbate ions have been investigated in a 1.0 M aqueous perchlorate medium as arnfunction of pH and temperature using stopped-flow and conventional UV-visrnspectrophotometry. Reductions of the anticancer active platinum(IV) complexes, dxms-rn[PtCl 4(NH3)( thiazole)] (1), /ram-[PtCl4(cha)(NH3)] (2), CM -[PtCl4(cha)(NH3)] (3), and cis-rn[PtCl 4(NH3)2] (4) by glutathione and of ( ram, ( vans, /ra/Ay- pPtCl2 (OH)2(cha) (NH3)] (5) (cha =rncyclohexylamine) by a series of thiols have been studied at 25 °C in the regions 2.00 < pH

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Mechanisms For Reduction Of Model And Anticancer Active Platinum(iv) Compounds By Biological Molecules

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