Mechanisms For Reduction Of Model And Anticancer Active Platinum(iv) Compounds By Biological Molecules

Electron transfer reactions of model and anticancer active platinum(IV) complexes with thiolsrnand ascorbate ions have been investigated in a 1.0 M aqueous perchlorate medium as arnfunction of pH and temperature using stopped-flow and conventional UV-visrnspectrophotometry. Reductions of the anticancer active platinum(IV) complexes, dxms-rn[PtCl 4(NH3)( thiazole)] (1), /ram-[PtCl4(cha)(NH3)] (2), CM -[PtCl4(cha)(NH3)] (3), and cis-rn[PtCl 4(NH3)2] (4) by glutathione and of ( ram, ( vans, /ra/Ay- pPtCl2 (OH)2(cha) (NH3)] (5) (cha =rncyclohexylamine) by a series of thiols have been studied at 25 °C in the regions 2.00 < pH

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