Hematological Parameters Of Patients With Thyroid Dysfunction At S.t Pauls Hospital Millennium Medical College Addis Ababa Ethiopia

Background: Thyroid hormones have a decisive role in metabolism and proliferation of bloodrncells and blood cells indices. Thyroid dysfunction leads different effects on blood cells such asrnanemia, leukopenia, thrombocytopenia, and in rare cases causes pancytopenia. rnObjectives: To determine hematological parameters of patients with thyroid dysfunction at S.trnPaul‟s Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia, from March-rnAugust, 2020.rnMethods: A hospital based comparative cross sectional study was conducted from March tornAugust, 2020, at SPHMMC, Addis, Ababa, Ethiopia. Convenient sampling technique was usedrnfor comprising of a total of 180. Participants‟ socio-demographic and clinical information wasrncollected from hospital cards. Initially 10 ml of venous blood samples were collected in to twornseparated test tubes. The blood specimen in the plain tube used for measurement of TSH, T3 andrnT4 (Cobase e 411 immunoassay system). Sample in the EDTA tubes, used for CBC analysisrn(Beckman-coulter hematology analyzer). Descriptive statistics was used to express the sociorndemographic and clinical characteristics. Independent T test to compare mean value between therngroups, binary and multiple logistic regressions were computed to assess association be-tweenrnvariables using SPSS version 20. P value less than 0.05 were taken as statistical significant.rnrnResults: Of the 180 study participants, 74(41.1%) hypothyroidism and 49(27.2) hyperthyroidismrnand 57(31.8%) were apparently healthy controls. Of them 137 (71.1 %) were female, most in thernage group 26-39 years (84, 46.7%). The result obtained showed a statistically significantrndecrease in RBC count, Hb, HCT, MCV, PLT counts and MPV in thyroid dysfunction patients rnwhen compared with apparently healthy controls (p value

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