Background: Burnout is an important problem in health care professionals and nurses arernmore exposed to professional burnout due to their exposure to physical, mental, and emotionalrnstressors, which can lead to numerous complications in their personal, social, andrnorganizational life , which is a decrease in occupational well-being and an increase inrnabsenteeism, turnover and illness. rnObjectives - to find out the prevalence of nurseâ€™s burnout and to identify its determinant factorsrnin public hospital Addis Ababa, EthiopiarnMethodology -rnA cross-sectional descriptive study was conducted using structured self-rnadministered questionnaire in different department and with nurses working in 6 (six) publicrnhospitals in Addis AbabarnResults: A total of 502 questionnaires were distributed with response rate of 88%, which totalsrn440 participants. Were included in this study. 241 (54.8%) suffered from professional burnoutrnbased on its definition. Among the study participants 271(61.6%) ,114(25.9%) ,55(12.5%)rnwere Emotional Exhaustion( EE) high , moderate ,low respectively .on the other hand the scalernofrnDepersonalization( DP) of nurses were 169 (38.4%), 146(33.2%),125(28.4%) highrn,moderate and low respectively .the scale of personal accomplishment( PA) werern74(16.8%),129(29.3%).237(53.9%) ,high ,moderate, low respectively . Individual factors suchrnas demographic variables, sex, health problem (backache) has association with burnout. Workrnrelated factors such as work area, service year and organizational factors employment sectorrn(public hospitals) were also found to be determinants of burnout in this population.rnConclusions -Burnout rates high in- emergency unit, Gender, services area, service year,rncurrent work satisfaction, , health problem are determinants of burnout, as well asrnorganizational variables.rnRecommendation â€“Independent variables which are significant association with burnoutrnGender-;males, work area- ICU ,Service years-11-15, Job satisfaction, health problem arernsignificantly associated with nurses burnout .So public hospitals administrations and the Federalrnministry of health has to plan on coping strategies to prevent burnout.