Introduction: Collaboration between Nurses and Physicians is important in health institutionsrnwhere most activities are team-performed. Ineffective nurse-physician collaboration affects patientrnoutcome, nurses’ job satisfaction and organizational cost and is challenged by personal,rninterpersonal and organizational factors.rnObjective: The aim of this study was to assess inter professional collaboration between nurses andrnphysicians working at Tikur Anbessa specialized Hospital.rnMethod: Institution based descriptive cross sectional study was employed from March to April,rn2015 using self- administered questionnaire. Systematic random sampling technique was used tornselect 293 professionals. Data was entered using epi info version 3.5.3 and exported to SPSS versionrn20 for cleaning and farther analysis. Descriptive statistics was presented by frequency tables,rnpercentages and measures of central tendency and dispersion. Student t-test was used to evaluaternmean difference and p-value