The management of health care waste is of great importance due to its infectious andrnhazardous nature that can cause undesirable effects on humans and the environment.rnThis study deals with the assessment of the existing practice, challenges and drawbacksrnof the HCWM of Bole 17 healthcare center. Descriptive research design was used. Bothrnprimary and secondary data have been used. Primary data has been collected throughrnthe use of questionnaires, interviews, personal observation. The researcher chose thernrespondents of this study using non probability sampling procedures. The questionnairesrnwere designed in order to get the feedback from the Healthcare center about the existingrnwaste management practice of Bole 17 healthcare center, interviews conducted with therncleaners of the healthcare center who are the most expected exposed parts. The researchrndata analysis mainly used qualitative data analysis methods using Microsoft excel. Thernstudy identifies the existed waste management practice, challenges it faced during thernapplication of the waste management, awareness gaps on segregation, collectionrntransportation and disposal of wastes. The question of how this healthcare centerrnmanages its waste is a subject of contestation. The study revealed that the reasons forrnlow performance of HCWM in the healthcare center includes: Poor awareness, shortagernof enough and appropriate space for waste disposal, insufficient PPE , lack of Budgetrn,low standard of incinerator, Poor roll of the EPA and poor implementation andrncontrolling mechanism and absence of certification system. The MOH and EPA inrngeneral and healthcare institutes in particular did not give attention to the HCWMrnunlike the IP and as a result staff members, beneficiaries and nearby residents arernfacing different health problems because of the unsafe management of hazardousrnwastes. The MOH, EPA and other stakeholders need to revise the existing system andrntheir policy to incorporate this risk issue. Thus, the researcher recommends that therncurrent waste management practice needs to improve its wastes management practicernby arranging awareness creation program, allotting its own budget, working inrncollaboration with EPA, and adopting auditing and certification mechanismsrn,minimizing or reducing the existed challenges and revising and adopting or developingrnpractical policy