Food contains a wide range of essential metallic and other mineral elements like zinc, selenium (Se), mercury (Hg), chromium (Cr). The presence of such minerals in food matrix has positive and negative impact on the consumer. Therefore, determination of the content of mineral in food matrix. To determine the above minerals, first samples were collected from Nifas silk Lafto, Akaki and yeka sub-cities and then samples got digested. Finally the total chromium, mercury and selenium were determined. The total content of mercury in tomato, red onion, soil are 75.25 ± 0.375 ng/g, 77.68 ± 0.975μg/kg, 49.23±0.275ng/g respectively (This is mean of Nifas Silk Lafto and Akaki Sub-cities). It wasn‟t detected in waste water, bread and injera. The level of chromium in tomato, red onion wastewater, and soil are 18.50±2.00mg/kg, 14.50±1.00μg/g, 187.25±4.25mg/L, 122.00±7.50±μg/g in that order. It wasn‟t detected in bread and injera. And also the concentration of selenium in red onion, tomato, soil, wastewater, injera and bread are mean± SD 8.015±0.035μg/kg,4.80±ng/g, 2.40±0.15μg/kg, 1.275±0.125ng/mL, 7.875±1.475μg/kg and 1.55±.05ng/g respectively. In all minerals, there is no significant difference within column (area), that implies rejection of alternative hypothesis at p