Assesment Of The Immune Status Of Hiv Positive And Hiv Negative Individuals With And Without Intestinal Parasitic Infections

Several features of the Acquired Immunodeficiency Syndrome (AIDS) epidemic inrndeveloping countries make it different from the epidemic in the industrialised world. Fasterrnrate of progression to AIDS and death, and a higher risk of infection after exposure to myrnare reported from developing regions of the world. Differences in natural history of HIYrninfection in developing versus industrialised countries might be related to differences in thernimmune status and responses of the patients. This might be due to exposure to mUltiplernpathogens in the former countries, among which intestinal parasitic infections are the mostrncommon. The objective of this cross-sectional study is to assess the immune status of myrninfected individuals with and without intestinal parasites and to determine the effect ofrntreating parasitic infections on some immunological markers of the patients. Yariousrnimmune cell subsets were examined by means of flow cytometry, using an extensive panel ofrnmonoclonal antibody combinations on my seropositive subjects and healthy controls withrnand without parasitic infections (n=80). Pre and post parasite treatment analysis was carriedrnout in my seropositive (n=5) and seronegative (n=6) individuals. Stool specimens of allrnstudy subjects were examined for intestinal parasites using both direct and concentrationrnmethods. Decreased proportions of CD4+ cells and increase of CD8+ T cells were observedrnin the my seropositive subjects. As would b~ eX'pecte

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