Abbay basin is one of the largest basins of the western drainage system located in the north westrnof Ethiopia. It accounts 17.5% of land area and 50% of annual average surface water resources ofrnEthiopia. It is also characterized by high population pressure, improper land-use planning, overrndependency on agriculture as source of livelihood, which is causing deforestation, overgrazing,rnexpansion of agriculture to marginal lands and steep slopes. These have resulted in decliningrnagricultural productivity and resources use conflicts in many parts of the Abbay basin. As arnconsequence of poor land use practices and improper management systems there are high soilrnerosion rates, sediment transport, and loss of agricultural nutrients. The total soil eroded withinrnthe landscape in the Abbay Basin is estimated to be 302.8 million tones per annum. In contrary,rncurrently the government has multitude plan to implement development projects with regard tornIrrigation, Hydropower and water supply to ensure food security and sustainable development.rnTherefore, knowing the estimate of annual sediment withdrawal is important in the planning,rndesign and operation of water resources development projects. Generally, this study is aimed atrnconducting regional sediment yield estimates for Abbay River basin using statistical multiplernregression relationships based on catchment characteristics and Rainfall. Sediment yield of aboutrn27 selected sub basins/stations are computed from suspended sediment concentration (SSC) andrndaily flow records. Other factors affecting sediment yield (catchment area (A), precipitation (P)rnis obtained from rainfall data of the station, whereas vegetation index (VIDX), slope indexrn(SLDX), soil index (SIDX) are catchment characteristics determined by running SWAT2005 forrnthe basin. The statistical multiple regression models, for estimating the regional sediment yield isrnapplied, using sediment yield, precipitation and catchment characteristics data once the selectedrnsub basins are regionalized. Hence the regression parameters are obtained for the regressionrnequation with coefficient of determination near to unity. Generally the equation developed willrngive preliminary sediment yield estimate for concerned individuals, institutions, stakeholders, etcrnfor any water resource development project.