The low utilization of maternal health care services and high risk of infant death has been and still isrna serious problem of Amhara region of Ethiopia. Maternal and infant health care issues continue tornoccupy a prominent place on the public health Agenda and National Population Policyrnimplementation. Prenatal and delivery care is emphasized in this study as a crucial intervention forrnreducing the risks of adverse outcomes of infants' death. Using Data from 2000 EthiopianrnDemographic and Health Survey Conducted by Central Statistical Authority (CSA), this studyrnexamines the status relationship and identifies the different factors associated with prenatal andrndelivery care on infants survival in Amhara region of Ethiopia.rnA total of 3713 infants of Amhara region were selected in the study. Both descriptive and inferentialrntechniques were used to analyze the DHS data. The univariate analysis is used to see the percentagernshare of background variables, while the bivariate and multivariate analysis were employed tornexamine the net effect and risk factors of prenatal and delivery care factors on infant survival. Thernfindings indicate the access to utilize the services is very low and its impact on infants' survival isrnadverse. Only 1 in 5 infants mother received prenatal care and the majority of birth (97%) occurredrnat home in the five years preceding the survey. While the infant mortality rate was high to 112 perrn1000 live birth in the year 2000.rnThe bivariate analysis using the chi-square test showed the existence of association between thernmaternal health care (prenatal delivery care factors), socio economic demographic factors andrninfants'survival. The multivariate results using logistic regression Model assessed the probability ofrninfants' survival examining the independent strength of maternal health care factors alone in Modelrn1 .. socio economic and demographic factors in Model 2 and the effect of the whole factors in Modelrn3. The result revealed that prenatal and delivery care and the Socio economic, Demographic factorsrnexerting a Significant effect on infants' survival.rnFinally, improvement in the access of utilizing the services, expanding the immunization of pregnantrnwomen, improving mothers education, the quality and quantity of safe water, extended duration ofrnbreast feeding through expansion offamily planning for spacing and raising the mothers age at birthrnand minimum age of mothers at marriage are among the recommendation of the study.