This study examines variations in childhood mortality between Misrak GOJjam andrnWag Hemra Zones of the Amhara Regional State. Misrak Gojjam is relatively more accessiblernthan Wag Hemra and by indicators such as food security, the former is much better than thernlatter. The thrust of the study is to compare the two zones in terms of the correlates ofrnchildhood mortality using the data generated by the Census of Population and Housing ofrnEthiopia of 1994.rnChildhood mortality is found to be relatively higher for Misrak Gojjam Zone thanrnWag Hemra Zone. If we exclude information from the first and the last two age groups ofrnwomen in the reproductive age, childhood mortality had shown a declining trend in the recentrnpast for each zone. In spite of the fact that Misrak Gojjam is relatively more accessible,rnrelatively free from the problem of food insecurity and less affected by the last civil war thanrnWag Hemra, child mortality is higher in theformer than in the latter.rnUsing Trussell and Preston (/98 I) dependent variable (the ratio of observed tornexpected deaths) that can be used for statistically sound childhood mortality studies, andrncontrolling for twelve explanatory variable in the model. the proportion of children deadrnamong children ever born was 11.0 per cent higher in Wag Hemra Zone compared to MisrakrnGojjam Zone. In addition, the study revealed zonal variations in signs and strengths of therninterrelationships between childhood mortality with its covariates. The general level of thernsocia-economic facto rs, and ecological settings may be the possible reasons f or such anrnohserved variations in childhood mortality between /he two zones.rnIt can be concluded from this study that relatil'ely drought prone ( food insecure) andrnremote areas need priority attention, indeed wi/hout ignoring other areas in the Amararnregion Finally, further studies concerning childhood mortality are highly recommended.