Blood Clotting Effect In Vitro And Wound Healing Activity In Vivo Of Fresh Juice And Ethanolic Extracts Of Croton Macrostachyus Leavea In Male Wistar Albino Rats.

Background: The plant remedies (both single plant and multi-herbal preparations) are used to rnpromote wound healing since ancient times even if the mechanisms of action, toxicity andrnefficacy of very few of them have been evaluated scientifically. Preparations from plant sourcesrnhave been traditionally considered effective to stop bleeding and promote wound healing. Juicernextract from leaves of Croton macrostachyus has been traditionally used as a local haemostaticrnmedicine to hasten clotting, however, this effect had not been tested in controlled experiments.rnAim: There was no scientific evidence justifying the use of Croton macrostachyus, therefore thernpresent study was aimed at evaluation of platelets aggregating and wound healing activity of thernplant.rnMaterials and methods: In the present study the Leaves of Croton macrostachyus were studiedrnfor procoagulant and wound healing activity by using ethanolic and fresh juice extract. Thernprocoagulant activity was studied by using the effect of extracts on platelets aggregation. Woundrnhealing activity was studied in excision model in rats, wound contraction, period ofrnepithelization, hydroxyproline estimation and histopathological examinations were studied.rnResults: Ethanolic extract induced significant (P

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