Background: Most elders in elders‟ home setting are suffering from lack of meaning in life allrnover the world. A study done showed it 43.6% of elder in elders home have low meaning in life.rnObjectives: To Assess Psycho-social wellbeing and meaning-in life among elders in elders‟rnhome setting, Addis Ababa, June 2015rnMethods: The study was employed an institution based cross-sectional study design by usingrnboth qualitative and quantitative methods starting from April to May, 2015. Systematic samplingrnmethod was used to select the 330study participants. The quantitative study was assessed usingrnMeaning-in-life test measurement scale and Multidimensional well-being measurement scale.rnThe qualitative study was assessed using in-depth interview and focus group discussion. Datarnentering, coding and clearing was performed using Epinfo window version 3.5 and the analysisrnwas done using SPSS window version 20 for quantitative data manual thematic analysis wasrndone for the qualitative study.rnResult: A total of 330 study participants were included in this study with response rate ofrn100%.Majority of the study participants317 (96.1%) reported bad psychosocial wellbeing,rn10(3.0%) reported wellbeing and 3(0.9%) reported high wellbeing. The mean score ofrnpsychosocial wellbeing is 1.0485 with SD of 0.25399 [female scored (1.0640, SD 0.30438) andrnmales scored (1.0390, SD 0.21792)]. Majority of participants 306(92.7) reported lack of clearrnpurpose and low meaning in life, 16(4.8%) reported moderate meaning in life and only (2.4%) ofrnelders reported high meaning in life. Family relationship, religion, activities and staff relationshiprnhave great impact in psychosocial wellbeing and meaning in life of elders. Elder home found tornhave association with meaning in life and Psychosocial well-being. Psychosocial wellbeing andrnmeaning in life have significance association (AOR=0.014, CI 0.003, 0.056).rnConclusion and recommendation: The state of psychosocial and meaning-in life is bad in mostrnElders. Elders‟ home have significance association with meaning in life and psychosocialrnwellbeing life. Therefore, Management personnel who manage the elders‟ home and staffrnmembers‟ needs to improve the living environment and arrangement as the whole contributing tornimprovements in elders‟ living environments.rnKey words:psychosocial needs, psychosocialIXrnwell-being and meaninginlife.