Glues are an adhesive which are collected by persistent boiling of animal skin, hide trimmingsrnand flesh from the slaughter houses. They can also be gathered from the scrap of animal skin andrnhide residues of leather industry. This study was aimed at determining the optimum condition forrnthe production of high quality glue from tannery solid waste. In other word, the effect of type ofrnreagents used (such as lime and sulfuric acid), concentration of reagents, boiling time, soakingrntime and boiling temperature were investigated. The pelt was treated with 2.5% and 10 %rnconcentration of reagents. Under sulfuric acid solution the pelt was soaked overnight and boiledrnfor 2 and 4 hrs at 70oC and 80oC, whereas it was kept for 2 and 4 weeks under lime solution andrnboiled for about 4 hrs at 70oC and 80oC. Generally, the glue produced by using lime showedrnrelatively high quality than the one produced from sulfuric acid. It was possible to extract highrnamount of glue within a short period of time from sulfuric acid treated pelt as compared to limerntreated one. Under lime medium, the adhesive strength of glue was increased with thernconcentration and soaking time and decrease with temperature. Soaking of the pelt, in 10% limernsolution, for 4 weeks and boiling at 70oC were found to be the optimum conditions for thernproduction of commercially viable glue. At this condition, the viscosity, yield and mass ofrnresidue was 255.05 mP, 0.1357g / g of pelt and 0.32287 g/ g of pelt, respectively. The economicrnfeasibility study, carried out in this work, showed that the project is to be financially viable withrnthe rate of return of the project 27.9%, the payback period of 3.08 year and the net present valuernof 40,036,155.25 birr.rnKey word: Glue, Protein, Quality, Tannery solid waste and viscosity