High strength concrete (HSC) has been used in the lower story columns of high rise buildingsrnowing to its qualities over normal strength concrete (NSC) in many countries. But, the fullrnstructural qualities of the HSC were unable to be used because of insufficient informationrnregarding the structural behavior of the material and its properties were not adequately addressedrnin building codes including EBCS. Analytical study was conducted at structure level torninvestigate the effect of using HSC column on the structural behavior of regular models ofrnmedium to high rise frame buildings under seismic lateral load in addition to gravity loads.rnConcrete strength variations of C30 to C90MPa were applied on the columns of the framernmodels. The proposed properties of the HSC class were incorporated in the analysis and designrnof the columns. The frames analysis was done using ETABS and columns were designed basedrnon the EBCS column design procedure.rnColumns moment- curvature curves were developed and maximum interstorey drifts werernobtained for the different frame models with variation in columns concrete strength. The studyrnshows that frames with HSC columns have got lower stiffness and performed well in satisfyingrnductility demand. The maximum interstorey drifts are slightly higher for frames with HSCrncolumns, but the contribution of the concrete strength in resisting the lateral deformations wasrnsignificant. Economic comparisons were also made and it was found that the most economicalrnframe corresponds to frame with the highest columns concrete strength.