A cross sectional study was conducted at Bishoftu and Addis Ababa Abattoirs fromrnSeptember 2017 to May 2018 to estimate abattoir based prevalence of tuberculosis in swine,rnto isolate Mycobacterium species involved and to characterize the lesions. Five hundred andrnfifty six (556) swine were examined. Tubercle like granulomatous lesion were detected inrn19.6% (109/556) of different organs of which 12% (69/556) was in lymph nodes, 5.7%rn(32/556) in the lungs, 1% (6/556) in the liver and 0.36% (2/556) in the spleen. Based onrnmicroscopic changes 4.7% (26/556) of lesions were tuberculous granulomatous type withrncentral necrosis, calcified foci, epitheloid cells admixed with lymphocyte and connectiverntissue boundries, 3.6% (20/556) pyogranulomatous and 2.5% (14/556) non necroticrngranulomatous lesion without epitheloid cells and connective tissue capsules. In lymph nodes,rnsevere depletion of lymphocytes, calcification, cellular debris and aggregation of macrophagesrnwere observed microscopically. The tuberculous lesions found in lymph node werernstatistically significant (P < 0.05) than in other organs. The multivariable logistic regressionrnanalysis showed that old aged swine were more likely to have characteristic tuberculous lesionrn(OR = 3.14, 95% CI, 1.62-6.09) than younger ones. From the tissue cultured, 7.5% (3/40)rnyield growth on primary culture media. The observed colony morphology was smooth whitishrnor yellowish color, sticky, off-white and breaks apart easily and two (5% (2/40)) of theserngrowth were acid fast positive by Zeihl-Neelsen staining technique. Based on culture result,rnand typical histopathologic lesions it could be concluded that pork can be source ofrntuberculosis to human when consumed under cooked and routine abattoir inspections shouldrnbe conducted. Therefore, further molecular and biochemical research to isolate the species ofrnmicrobacteria is highly recommended to elucidate the type of lesion and its magnitude inrndifferent body organs by considering large number of swine.