Background : Laryngospasm is defined as the sustained closure of the vocal cords, well-knownrnproblem typically occurring immediately following tracheal extubation. This blockage can leadrnto hypoxemia, negative-pressure pulmonary edema, pulmonary aspiration, and cardiac arrest.rnIncidence of laryngospasm is as high as 25% in patients undergoing tonsillectomy andrnadenoidectomy. Propofol is an intravenous drug use for the induction of general anesthesia andrnfor moderate to deep sedation, which is also known to strongly suppress airway responses. At arnlower concentration than the anesthetic dose, propofol may help to reduce or preventrnlaryngospasm after extubation in pediatric patients rnObjective: To determine the effectiveness of propofol to prevent laryngospasm during adenoidrnand tonsillectomy cases under general anesthesia. rnMethods: In this institutional based prospective cohort study 66 pediatric patients age up to 9rnyears were included. It was conducted from December 2019-March 2020 at Tikur Anbessarnspecialized hospital, Yekatit 12 hospital and Menilke hospital, pediatric patients who scheduledrnto undergo elective tonsillectomy with or without adenoidectomy under standard generalrnanesthesia who fulfilled the inclusion criteria were included in the study. The data was recordedrnas group P if anesthesia providers gave suphypnotic dose of propofol(0.5mg/kg) one minuternbefore extubation as well the data were recorded as group C if the anesthesia provider justrnextubate without giving propofol. Normality of the data was checked using Shapiro-Wilk test andrnanalyzed using student t test for normal distributed data and chi-square test for categorical data.rnNon- parametric data was analyzed using Mann â€“Whitney U test with 95% CI and p- value lessrnthan 0.05 is considered as statistically significant. rnResult: Comparison of data from Propfol group and Control group using chi square showed thatrnoccurrence of laryngospasm was significantly lower in P group then group C (9.1 Vs. 42.4) withrnp-value less than 0.05. With no significant difference in the severity of laryngospasm and vitalrnsign changes between groups. rnConclusions and Recommendation: Subhypnotic dose of propofol (0.5 mgÃ†kg)1) decreases thernoccurrence of laryngospasm upon tracheal extubation in children undergoing tonsillectomy withrnor with out adenoidectomy. We recommend anesthetists to use 0.5mg/kg of propofol one minuternbefore extubation to prevent postextubation laryngospasm. And we also recommend furtherrnrandomized control trial in order to avoid bias.