In Ethiopia many medicinal plants are used for the treatment of malaria including Dodonaearnangustifolia seed with out considering their side effects. Therefore, the present study attemptsrnto evaluate the chronic effect of crude extracts of D. angustifolia seeds on somernhematological and biochemical parameters and histopathology of liver and kidney of mice.rnFor the chronic treatment, animals were administered with the crude extracts of the plantrnthrough the oral route using oral gavage for six weeks at doses of 400 mg/kg/bw and 800rnmg/kg/bw of the aqueous extract and 400 mg/kg/bw and 600 mg/kg of the methanolic extract.rnAt the end of the experiment, all mice under treatment were sacrificed after blood collectionrnfor hematological and biochemical analysis and liver and kidney sections were randomlyrntaken for tissue processing. The results of hematological and biochemical analysis as well asrnthe microscopic examinations of the liver and kidney sections were compared with controlrngroups. The hematological and biochemical results showed no statistically significantrndifferences between the aqueous extract treated mice at both doses of 400 mg/kg/bw and 800rnmg/kg/bw and the control group. In contrast, statistically significant elevation in ALT, AST,rnurea and creatinine were observed in methanolic extract treated mice at a dose of 600rnmg/kg/bw as compared to the control group. Histopathological examinations of the liver andrnkidney sections of aqueous crude extract treated mice at both doses of 400 mg/kg/bw and 800rnmg/kg/bw showed similar histological appearance as that of the control group except somernfocal inflammation were observed around central vein at dose of 800 mg/kg/bw of thernaqueous extract of the plant. In contrast, significant histopathological changes were observedrnin liver and kidney sections of methanolic crude extract treated mice at dose of 600 mg/kg/bwrnwith focal cellular infiltration around central vein of the liver sections at 400 mg/kg/bw rnshowing the dose dependent effect of methanolic crude extract of the plant. In conclusion, thernaqueous crude extract is safe to use at effective dose of 400 mg/kg/bw whereas thernmethanolic crude extract of D. angustifolia at the same effective dose (400 mg/kg/bw) as thatrnof aqueous crude extract has slight toxic effect but adversely affects the biochemicalrnparameter and histology of liver and kidney as the dose level increases to 600 mg/kg/bw. Asrnthe aqueous extract did not show adversity at the effective dose, it is recommended thatrnmedicinal plant users choose the aqueous extract of the plant. Further investigation is alsornrecommended to isolate metabolites that may contribute the toxic effect of methanolic crudernextract on liver and kidney.