The Application Of Facilitated Ion Transfer Across Membrane Stabilized Interface Between Tow Immiscible Electrolyte Solutions In Clinical Analysis

AC and DC voltammetry and flow injection amperometry methodsrnwere employed in this work. The influence of ionophores on thernfacilitated transfer of K+ and Na+ ions across membranernstabilized water/nitrobenzene interface was investigated.rnAccording to this investigation benzo 15 crown 5 (B15C5) wasrnfound best for K+ ion and dibenzo 24 crown 8 (DB24C8) for Na+.rnB15C5 was an appropriate ionophore in simultaneousrndetermination of K+ and Na+ ions. DB24C8 was found to be poorrnin this regard. Stability constants of metal-ionophore complexrnwere estimated. The values forK+ -ionophore (K-DB24C8, KDB18C6)rnwere in good agreement with literature values, whilernthose of Na+-ionophores (Na-DB24C8, Na-DB18C6) are higher thanrnthe literature values. Concentrations of Na+ and K+ in bloodrnserum were determined simultaneously using flow injectionrnamperometry and flame photometry. The results obtained fromrnvoltammetric and flow injection amperometric investigationsrnindicate that the membrane stabilized interface is a promisingrnas a voltammetric sensor in clinical analysis of bloodrnelectrolytes

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