The highly competitive and allergic weed Parthenium hysterophorus was introducedrnto Ethiopia in 1970s. The weed has spread to the most parts of the country with highrninfestation rates in grasslands and even in crop fields. It is a growing danger to smallscalernfarmers: tef and sorghum grain yields are reduced; milk output from dairy cows isrndecreasing to one third; the milk has sour taste; animals suffer from skin allergy andrnreduction in weight; farmers suffer from skin allergy, itching, fever and asthma; intensivernlabour input has to be made in order to clean the crop fields. So, Parthenium is a currentrnthreat for further economic development in the rural areas of Ethiopia. Differentrnparthenium controlling methods were established, but no single method appearedrnsuccessful as each suffered with one or more limitations. This study presents the findingsrnof a study conducted to evaluate the biogas and fuel birquetting potential of partheniumrnweed to manage the spread of parthenium weed through utilization. Parthenium wasrnmixed with cattle manure in different combinations at a level of 3:1 ,2:1 , 1:1 , 1:2rnratio, parthenium alone and cow dung alone and allowed to digest anaerobically atrnambient temperature in 2.5-litre batch digesters. The highest total gas yields werernobtained from 1:1combination as 9922 ml and the lowest was from cow dung alone asrn3096ml., the highest biogas potential was observed for treatment 1:1 combination asrn0.082308 m3 biogas kg-1VS added and the lowest biogas potential was observed fromrntreatment T1 as 0.03458 m3 biogas kg-1VS added. The highest COD removal efficiencyrn82.93% and biogas potential 0.1824 m3 biogas kg-1VS added was for treatment T3(1:1)rnwhereas the lowest COD removal efficiency 45.34% was for T6(3:1) . The highestrnvolatile solid VS) conversion efficiency 88.95 % was for T3 and the lowest conversionrnefficiency 50.30% was for T1. The percentage of methane gas for treatment T4 obtainedrnwas 47.2% and similarly, the methane percent of the biogas for treatment T3 and T5rnobtained from gas chromatography and gas chromatography mass spectrometer wasrngreater than 50%. Among the best three treatments T3 (1:1) ratio was with highest peakrnarea and methane percent of the biogas. In this study Parthenium weed was also maderninto fuel briquette and the moisture content, volatile matter, ash content, fixed carbon,rnbulk density and calorific value of parthenium briquette were measured to be 4.10Â±0.06,rn16.63Â±0.34,20.12Â±0.05,57.17Â±0.55,0.297Â±0.068,3907Â±0.88respectively.