This study attempts to examine/asses the right to self-rule and large scale of agriculturerninvestment in Gambella National Regional State western Ethiopia, based on the assessment onrnthe self-rule, socio-economic and environmental effects of large scale agriculture landrninvestment/transfer on local people’s livelihoods. The analysis of this research followedrndescriptive qualitative research approach. The primary data was collected through key informantrninterviews, focus group discussions and direct observation by the author. To complement thernprimary data, secondary data which the researcher found from government legal documents andrnvarious published and unpublished sources were used. After analyzing the data collected, thernstudy found that the transfer of large scale agriculture investment on land to domestic andrnforeign investors have brought no significant social benefits to the local communities, politicalrneconomic as measured by the level and type of technological transfer, creation of employmentrnopportunities and level of food crop production. However, some Large Scale AgriculturalrnInvestment to investors has helped improve infrastructure. The study also found that therninvestment has negative effects on the self-rule, local small scale farming or economies in termsrnof loss of crop land, grazing land, grass land, firewood and water resources; these havernnegatively affected local agrarian economies and animal rearing livelihoods. Moreover, therninvestments have negative environmental effects on the biodiversity resource as observed by thernscale of clearing of the indigenous vegetation cover, damage on wildlife, depletion of waterrnresources, exposed the land to soil erosion and soil degradation. Besides these issues, this studyrnidentified the coping strategies pursued by local communities in response to the effects of therntransfer of the large scale agriculture of their land and natural resources ownership to therninvestors. These strategies include changing land use, sharecropping, tenant farming, changingrnoccupation and mobility or migration patterns. Lastly, the research suggests/recommend somernideas for policy makers which emerged from the field study. They include suggestions for therngovernment, investors, stakeholders and civic societies.rnKey Terms: self-rule, Large Scale of Agriculture Investment (LSAI), Local Community,rnagribusiness Investment, Socio-economic effects, constitution, Coping Strategy