The Abo Blood Group And Plasmodium Falciparum Malaria In Awash Metehara And Ziway Areas Ethiopia.

The study aimed at investigating the relationship between blood group type and severe disease in P.falciparum malaria in three Ethiopian malaria endemic localities. A total of 210 cases of malaria (70 severe and 140 uncomplicated) and 190 healthy controls participated in the study. In the severe malaria category, there were 25 (35.7%), 15 (21.4%), 14 (20%) and 16 (22.9%) blood group A, B, AB and O patients respectively. Blood group O was the dominant blood type in both uncomplicated malaria (45.7%) and healthy controls (41.6 %). As compared to the uncomplicated malaria, a case of severe malaria was almost twice as likely to be of type A as to be of type O (O vs. A, odds ratio 0.42, 95% confidence interval 0.2007- 0.8789), and more than twice as likely to be of type B as to be of type O (O vs. B, odds ratio 0.38, 95% confidence interval 0.1638-0.8973), and in both cases the difference was statically significant (P=0.019 for O vs. A; P= 0.02 for O vs. B). Furthermore, individuals with severe malaria were about seven fold less likely to be of O as to be of type AB (O vs. AB, odds ratio 0.19, 95%; P=0.0005). There was significantly low mean hemoglobin concentration in the severe malaria patients than the uncomplicated malaria and healthy controls (P

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