This paper attempts to appraise the protection of the human rights of PWDs within the AfricanrnUnion human rights framework. Globally, the issue of disability has obtained a significantrnattention in recent years due to the fact that the rights of PWDs are not protected and promotedrnin all aspects of activities as equally as other non-disabled persons. In the African context too,rnnegative attitude, distorted public assumptions and stereotypes have been demonstrated in forms,rninter alia, of discriminations, segregation, neglect and abuse in access to employment, health,rnjustice, and other social services. Despite abject challenges encountering PWDs, the adoption ofrnthe Convention on the Rights of Persons with Disabilities (CRPD) by the United Nations GeneralrnAssembly implies how the issue of disability is sensitive and increasing concerns of governmentsrnand the international community. Hence, the adoption of this Convention is a collective effort ofrnall concerned organs as well as a critical response to a growing human rights pressure fromrnmany national and international organizations operating on human rights, mainly disabledrnpersons organizations (DPOs).rnAs members of the United Nations, many African countries have ratified the CRPD at nationalrnlevel, taking into consideration the complex and unfavorable situations facing PWDs in theirrnrespective contexts. Albeit talks about human rights can be traced back to decades, the generalrnattitudes of the society and the lack of awareness on the part of governments in Africa havernnegatively influenced the actual lives and rights of PWDs. Within the auspices of thernOrganization of African Unity/the African Union, fewer efforts have been exerted to bring aboutrnchanges in the prevention and rehabilitation of disabilities in the Continent. At regional levels, arnplethora of human rights instruments and institutions are adopted and organized to enforce thernhuman rights of all human beings and peoples of Africa. However, neither binding instruments,rnnor specific institutions dealing with the human rights of PWDs have come in to reality, exceptrncertain movements are underway to establish legal and structural frameworks in this regard.rnThus, this paper assesses the human rights of PWDs in light of international human rightsrninstruments briefly and, most importantly, the general situations of PWDs in Africa including thernhuman rights and institutional structures within the African Union human rights frameworks.