For the last two and half decades HIV/AIDS has been causing a great damage to human life.rnHIV remains a global health problem of unprecedented dimensions. Ethiopia is one of the subrnSaharan country affected by the epidemic. For instance, in 2005 there were 1,320,000 personsrnliving with HIV/AIDS in Ethiopia. There were 353 new infections and 338 deaths per day at thernnational level.rnHowever these days with the discovery of ART drugs, mortality rate decreased. Even thoughrnmortality rate decreased, there were problems created after the invention of the drug. Sincerntaking the drug needs >95% adherence which means not missing more than one dose perrnmonth to avoid the emergence of drug resistant HIV strains. Otherwise the virus will replicatesrnand mutates (changes its character, including its ability to resist drugs) at a very high rate. Nonadherencernby patients on ART has serious consequence both on the individual as well as thernsociety.rnAccording to different studies conducted through out the country, starting spiritual treatmentrnlike tsebel is one of the reasons for non adherence by patients. The belief that goes saying modernrnmedicine could not be taken with spiritual treatment (tsebel) by the Ethiopian Orthodox Churchrnhas been creating a problem for the past few years. However, the church has changed its standrnand started to educate the clergy about this issue.rnThe study uses qualitative method which includes in-depth interview and focus grouprndiscussion. The data is collected from two holy water site: Entoto Mariam church and Uraelrnchurch. The data is collected from four target groups which include: - Religious leaders, PeoplernLiving With HIV (Who are taking ART with tsebel and who stopped taking ART after theyrnstarted tsebel), Community leaders and Actors (Organizations who are working on HIV andrnrelated issues).rnEventually, the findings of the study show that there is awareness about ART and adherencernamong religious leaders, PLWHA and community leaders. The training given by EOC helped torncreate awareness and to make dialogue among religious leaders. As a result, there is found to be arnbehavioral change among religious leaders. They started advising PLWHA not to stop their ARTrndrug when they start tsebel. The communication between religious leaders and PLWHA isrnlimited to interpersonal communication (counseling) because religious leaders are notrncomfortable to talk about the compatibility of ART and tsebel in public. Even those religiousrnleaders, who are giving education in public, do it rarely. The absence of a written policy by thernchurch, scarcity of mass communication, and community resistance are some of the problemsrnthat are revealed by this study. To solve these problems, availability of policy, sensitization of therncongregants at public places and churches regularly, interpersonal communication withrnPLWHA and the use of Mass Media in the form of TV spots and radio dialogues arernrecommended.