The main objective of the study is to examine the practices and challenges of public relations onrnmarketing and promoting tourist destination sites in the region in the case of ANRS Cultural and TourismrnBureau. Most importantly, it examine the major public relations activities practiced in the bureau onrnmarketing and promoting tourist destination sites in the regions, the roles of public relations practitionersrndo bureau on marketing and promoting tourist destination sites, and the challenges of public relations onrnmarketing and promoting tourist destination sites in the region. The study used both qualitative as well asrnquantitative method, and the data collected through questionnaire and interview. Then, the quantitativerndata was analyzed comparing the mean with the expected mean and one-sample t-test, and the interviewrndata also analyzed through word description. Finally, the study found out that there was practice ofrnpublic relation in tourism bureau especially on marketing and promoting tourist destination sites inrnAmhara region. There was different communication tools in order to marketing and promoting touristrndestination sites such as TV program, radio, prints, You Tube and others though the effort that was madernin Gonder city by far than Bahir Dar city because Gonder city’s promote tourist destination sites throughrnBBC and CNN. Besides, there were executive and technician roles of public relations in their bureau onrnmarketing and promoting tourist destination sites though their effort was not found to be significant.rnHowever, most of the interviews indicated that the public relation officers were assigned without theirrnprofession and they did not have managerial role in the bureau, so they are working as technician. Inrnaddition, there were challenges of public relations on marketing and promoting tourist destination sites.rnThese can be lack of understanding among the staff (i.e. both top managements and staffs), lack ofrnequipments and resources, and others. Hence, we can assume that the public relation practitioners’ hadrnfaced challenges that affect marketing and promoting of tourist destination sites in the region. Finally,rnpossible recommendation forwarded.