Background: Khat (Catha edulis Forsk) is a plant mostly grown and used in east Africanrncountries and the Arabian Peninsula since ancient time with a progressive increase of use in thernrecent time. It is becoming an important concern worldwide and the khat producing countries inrnparticular for its stimulant effect.rnObjectives: This study was designed to assess the acute effect of khat ingestion on pulmonaryrnfunction and arterial hemoglobin oxygen saturation in human.rnMethodology: This experimental study was done in 20 study participants. Data gathering toolsrnincluded Biopac data acquisition systems for determination of FVC, FEV1, FEV2 FEV1%,rnMVV, VT, and NRR. Pulse Oxymetry was also used to measure oxygen hemoglobin saturation.rnThen, data obtained were analyzed using quantitative and qualitative techniques.rnResults: This study showed statistically significant increase (P