The chewing and ingestion of fresh and young leaves of khat producesrnobservable alterations in the physical, physiological and psychologicalrnwellbeing of man.rnThe aim of this study was to assess the effects of Khat on vital signs, lungrnfunction indices and electrocardiographic profile of the casual user. Sixtyrnhealthy adult men who were casually chewing Khat leaves were randomlyrnselected from 10 localities in Addis Ababa using inclusion and exclusionrncriteria. The mean age (±SD) was 31±2 years; their mean body weightrnwas 70.8±3.8 kgs, their BMI was 22.3±0.6 kg/m2. None were smokers andrntheir frequency of chewing and ingestion of khat leaves was on thernaverage 1.7 times per week. All study subjects had a normal P/E andrnhistory and normal V/S, LFI and ECG prior to the khat session.rnEach of the subjects was given 200 gm of fresh Beleche leaves to chew forrna period of two hours. All vital signs including arterial blood pressure,rnheart rate, and respiratory rate increased significantly (P