Background: Staphylococcus aureus is a gram-positive bacterium that can cause communityrnacquired and hospital acquired infections. Development of antimicrobial resistance has limitedrntreatment options against infections due to this pathogen.rnObjectives: To assess the prevalence of methicillin resistance Staphylococcus aureus amongrnpatients suspected for HAI and associated risk factors in admitted patients.rnMethods: A cross-sectional study was conducted from January 2018 to January 2019 torndetermine the prevalence of Meticillin Resistance Staphylococcus aureus and associated riskrnfactors Among Admitted Patients at TikurAnbessa Specialized Hospital, Addis Ababa, Ethiopia.rnSamples were cultured for S. aureus isolations according to (CLSI 2018). Isolates were tested forrnsusceptibility to panels of 14 antimicrobial agents using disc diffusion assay. Susceptibility tornmethicillin was phenotypically determined based on sensitivity of isolates to cefoxitin orrnoxacillin.rnResult: Out of 413 patients, a total of 160(38.7%) Coagulase positive S. aureus and 59(14.3%)rnCoagulase negative isolates were recovered from patients involved in the study. Out of 160rnisolates, 57 were MRSA. All 57 isolates of MRSA are 100% resistance to Cefoxitin, penicillin,rnaugumentin,Carbapenems and Cephalosporins. And 28.1%(16) resistant tornClindamycin,80.7%%(46) to Ciprofloxacin,91.2%(52) to Gentamycin, 61.4%(35) tornErythromycin, and 65%(37) Trimethoprim-Sulfamethoxazole respectively. Majority of therncoagulase positive isolates exhibited (n=160, 38.7%) multi drug resistance. The overall burdenrnof MRSA among the admitted patients were 57/413(13.8%). The prevalence of MRSA amongrnthe isolates in males and femalesâ€™ patients are 35(61.4%) and 22(38.6%) respectively. Durationrnof hospital admission length was not statistically significant in the acquisitions of MRSA in Chisquarerntest (where P value