The Study Of Malaria And Hivaids Co-infection Effect On Red Blood Cell Indices And Its Relation With The Cd4 Level Of Patients On Haart In Bench Maji Zonesouth West Ethiopia.

Background: Malaria and HIV/AIDS are the two most common infections in sub-SaharanrnAfrica and worldwide with the half of world’s population at risk of malaria and nearly 39.5rnmillion PLWHA. HIV infected individuals living in malaria-endemic areas experience frequentrnand severe malaria episodes. Although anemia is the most common hematological abnormality inrnMHC patients, results were inconsistent regarding anemia and RBC indices. In Ethiopia, threefourthrnofrnthernlandmassrnisrnmalariousrnwithrnthernprevalencernisrnhigherrninrnHIV.rnThisrnstudyrnwasrnaimedrnrntornrncompare RBC indices and anemia in HIV patients with CD4 level of co-infected and thosernHIV patients without malaria on HAART in Bench Maji Zone. rnMethods: A comparative cross-sectional study was conducted on 103 malaria-HIV/AIDS co-rninfected and 103 HIV patients without malaria. Data were collected using structuredrnquestionnaire and blood samples were collected from both groups. Data obtained was enteredrnand checked in Epi-data and exported to IBM SPSS version21 software packages for analysis. rnResults There were significant differences between the two groups (P≤ 0.001) in RBC indices.rnOf these values RBC count, Hgb, HCT and MCV were lower in MHC patients. There werernsignificant positive correlation between CD4count with MCV, MCH and anemia in totalrnparticipants. In MHC, CD4 count with RBC and Hgb while in OH infected CD4 count withrnMCV, MCH and MCHC were positively correlated significantly. Overall anemia was highrn(45.1%) and magnificent in MHC (63.4 %), female sex (61.3 %), falciparum-infected (37.6%),rnpatients with CD4 count of ≤500cells/μl (55.9%) and income below mean (63.4%).Anemia isrnmore prevalent among MHC patients with CD4 count of ≤500 cells/μl (59.32 %) while in OHrninfected it was equal in those with CD4 count of ≤500 and ≥500 cells/μl (50 %) There was arnsignificant difference in anemia in MHC and OH infected with different CD4 group (P≤0.01). rnConclusion: In our study there is a difference in RBC indices in MHC and OH infected patientsrnand the mean value of RBC, [Hgb], HCT and MCV is lower in MHC. In MHC there is a positiverncorrelation between CD4 count with RBC, and [Hgb]. Anemia prevalence is higher in MHC, inrnfemale sex, in falciparum infected and higher in patients with a CD4 count of ≤500 cells/μl.

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